The pickup truck was being driven by Wesley B. Martin, 39, of Gautier, Miss. He was dead at the scene, the State Patrol said.
Martin was driving eastbound on SR 548 east of Kickerville Road when he attempted to pass a semi in heavy fog, the State Patrol said. But his GMC pickup collided with an oncoming 1992 Nissan Sentra driven by Angela Rodrick, 18, of Blaine. She was dead at the scene, the State Patrol said.
The cause of the accident was listed as "unsafe pass" by the State Patrol.
Officers said visibility in the fog at the time was only about 50 to 75 feet.